With help from some Saints who managed to escape and hacked the simulation to give them superpowers, the player attempts to rescue their captured friends, escape the simulation, and defeat the Zin. Five years into their governance, they find themselves trapped in the Steelport simulation along with members of their gang, the 3rd Street Saints, after an alien empire known as the Zin attack the Earth and capture them. The single-player story follows the same player-created character from the previous games, who becomes elected President of the United States after thwarting a terrorist threat. It also incorporates science fiction elements, and continues the series' reputation for over-the-top parody. The game's open world nature allows players to freely explore a simulation of the fictional city of Steelport while completing main and side missions at their leisure. A Nintendo Switch port was released on Maand a Google Stadia port was released on November 1, 2021. The game was released in August 2013 for Microsoft Windows, PlayStation 3, and Xbox 360, and was later ported to PlayStation 4, Xbox One, and Linux in 2015. It is the sequel to 2011's Saints Row: The Third and the fourth installment in the Saints Row series.

Saints Row IV is a 2013 action-adventure game developed by Volition and published by Deep Silver.